在42250名接受了乳房切除术和放射疗法治疗的妇女中，有547名妇女在随访期间发生了同侧浸润性复发（1.3％），而在这547名患者中有163名妇女死于复发。 在接受乳房切除术（单侧或双侧）的25527名妇女中，有200名妇女经历了同侧浸润性复发（0.8％），同样，在这之中154名妇女死于浸润性复发。 LVEF 提示心脏毒性的常用标准是 : 低于阈（50%~55%）、蒽环类药物治疗期间LVEF的无症状下降>10% 或者在有心力衰竭症状的情况下下降>5%。 超声心动图受到声窗充分性和图像质量的限制，在敏感度方面不如CMR。CMR显示，心脏毒性的早期迹象是心包积液显著以及剂量依赖性增加和T2比值的临界显著增加[7]。 来源：乳腺癌互助圈 参考文献： [1] SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021. Epub ahead of print. [2] Bray F, Ferlay J, Soerjomataram I, Siegel RL, TORRe LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [published cORRection appears in CA Cancer J Clin. 2020 Jul;70(4):313]. CA Cancer J Clin. 2018;68(6):394-424. [3] Narod SA, Iqbal J, Giannakeas V, Sopik V, Sun P. Breast Cancer Mortality After a Diagnosis of Ductal Carcinoma In Situ. JAMA Oncol. 2015;1(7):888-896. [4] Sam G, Ho PJ, Rijnberg N, et al. Risk of death from cardiovascular disease following breast cancer: a systematic review[J]. Breast Cancer Res Treat, 2017, 164(3): 537- 555. [5] Foraker RE, Abdel-RASoul M, Kuller LH, et al. Cardiovascular health and incident cardiovascular disease and cancer the women's health initiative[J]. Am J Prev Med, 2016, 50(2): 236-240. [6] Abdel-Qadir H, Austin PC, Lee DS. A population-based study of cardiovascular mortality following early-stage breast cancer[J]. JAMA Cardiol, 2017, 2(7): 88-93. [7] Foulkes S, Claessen G, Howden EJ, et al. The utility of cardiac reserve for the early detection of cancer treatment-related cardiac dysfunction: a comprehensive overview[J]. Front Cardiovasc Med, 2020, 7:32.究竟是什么原因导致乳腺癌有如此居高不下的死亡率呢？
健康生活，积极心态
药物预防
心脏功能监测
